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| Pedroza,Heloisa de Paula; Ferreira,Marina Guimarães; Carvalho,Júlia Gomes de; Melo,Karla Dias Antunes; Keller,Kelly Moura; Melo,Marília Martins; Soto-Blanco,Benito. |
| Nerium oleander é uma planta ornamental responsável por intoxicações em animais e humanos. Todas as partes da planta contém glicosídeos cardiotóxicos, principalmente a oleandrina. Alguns autores apontam que a toxicidade da planta apresentaria variação em função da cor da flor. O objetivo deste trabalho foi determinar se existe variação na concentração de oleandrina nas folhas de N. oleander de exemplares da planta com diferentes cores de inflorescências. Foram coletadas 10 amostras de folhas para cada tipo de flor (branca, rosea e vermelha). Os níveis de oleandrina foram determinados por meio de HPLC-UV após extração com metanol, precipitação com acetato de chumbo e separação em cartucho de C18. A média da concentração obtida em todas as folhas analisadas... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Apocynaceae; Plantas tóxicas; Cardiotoxicidade; Glicosídeos cardíacos; Cardenolídeos. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782015000500864 |
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| Telles,Thalita da Costa; Botelho,Ana Flávia Machado; Miranda,Ana Luisa Soares de; Soto-Blanco,Benito; Serakides,Rogéria; Ocarino,Natália de Melo; Melo,Marília Martins. |
| ABSTRACT: The aim of this study was to evaluate the use of mesenchymal stem cells (MSC) in the treatment of myonecrosis induced by Bothrops alternatus venom in rats. Seventy-five male adult Wistar rats were divided into three experimental groups. G1 and G2 were injected in the gastrocnemius muscle with 120μg of B. alternatus venom, while G3 received 200μL of PBS only. Three days after the venom injection, 12 rats from G1 were treated with 5.0 x 106 MSC in PBS, whereas G2 and G3 rats received PBS. Every three days, blood and muscle samples of five animals from each group were taken for serum biochemical and pathological analyses. Histological examinations showed more intense muscle lesions following MSC treatment, characterized by disorganization and loss... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Viperidae envenomation; Stem cells; Rats; Myonecrosis; Muscular repair. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018000300602 |
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| Carvalho,Ciro José Sousa de; Melo,Marília Martins; Michell,Ana Flávia Ribeiro Machado; Torres,Bruno Benetti Junta; Riet-Correa,Franklin; Guedes,Roberto Maurício Carvalho; Ferraz,Vany Perpetua; Soto-Blanco,Benito; Silva,Silvana Maria Medeiros de Sousa. |
| ABSTRACT: In Brazil, at least 16 poisonous plant species can affect the central nervous system of livestock. Recently in the state of Piauí, Northeastern Brazil, Brunfelsia uniflora was reported as a cause of nervous signs in donkeys, cattle, and small ruminants. In order to assess the toxicity of B. uniflora extracts, 20 Swiss mice were distributed into four groups (n=5) receiving by gavage alkaloids, flavonoids, saponins, or saline (control group). After administration of the extracts in a single dose (5g kg-1), all mice were observed daily for clinical signs. Mice that received the extracts showed moderate to severe clinical signs, including piloerection, vocalization, and seizures. All mice dosed with saponins died between 10 and 20min after... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Toxicity; Alkaloids; Saponins; Flavonoids; Brunfelsia; Solanaceae. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018000100552 |
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| Geraldo Neto,Severino Antonio; Sakamoto,Sidnei Miyoshi; Soto-Blanco,Benito. |
| Foi realizado um estudo para determinar as plantas tóxicas incriminadas como de interesse zootécnico em 35 municípios das mesorregiões Central e Oeste do estado do Rio Grande do Norte (RN). Foram entrevistados 180 produtores, 20 médicos veterinários, 12 técnicos agrícolas e 5 agrônomos. Os dados obtidos nas entrevistas foram compilados e analisados com auxílio do programa Epi Info versão 6.04. As plantas tóxicas relatadas pelos entrevistados como causadoras de diversos surtos foram Ipomoea asarifolia, Aspidosperma pyrifolium, Indigofera suffruticosa, Manihot carthaginensis subsp. glaziovii, Amorimia septentrionalis, Tephrosia cinerea, Anadenanthera colubrina var. cebil, Marsdenia megalantha, Anacardium occidentale, Cnidoscolus quercifolius, Crotalaria... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Intoxicações por plantas animais de produção semiárido; Epidemiologia. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782013000700022 |
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| Câmara,Antônio Carlos Lopes; Castro,Márcio Botelho de; Calado,Eraldo Barbosa; Soto-Blanco,Benito. |
| ABSTRACT: In cattle, abdominal tumors leading to partial or total intestinal obstruction are rare. Here, it is described the clinico-pathological findings of two cows with intestinal obstruction by neoplasms. A crossbred cow presented apathy, weight loss, constipation, enophthalmos, ruminal and intestinal hypomotility, and abdominal distension in the right ventral quadrant. Pathological examination revealed bilateral ovarian teratoma. The other case was a cow that in the past 2 years had several episodes of squamous cell carcinoma in the third eyelid and vulva. During the 6 days prior to investigation, clinical signs of constipation and tenesmus were noted. Nodular and friable masses were located in the vulva, right third eyelid and cranially to the right... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Abdominal tumors; Intestinal obstruction; Metastatic adrenal carcinoma; Ovarian teratoma. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000701252 |
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| Câmara,Antônio Carlos Lopes; Passos,Marcel Batista dos; Peneiras,Anna Beatriz Veltri; Pereira,Júlio Rafael de Melo; Teixeira Neto,Antonio Raphael; Soto-Blanco,Benito. |
| ABSTRACT: Ossifying fibroma is a disfiguring benign neoplasia of the jaw that affects young animals of several species, including horses. The present report described the postoperative care and long-term follow-up after a rostral mandibulectomy (RM) that was performed to treat an ossifying fibroma in a horse. A 3-year-old crossbred horse presented a hard, well-defined, 14.5×10.0×9.5cm ulcerated mass attached to the rostral mandible. Radiographic findings were compatible with a nonaggressive mandibular bone deformity (benign neoplasia). Histological features confirmed the diagnosis of the ossifying fibroma. After the RM, the horse slowly adapted to the new feeding conditions and was discharged when it fully recovered and was capable of feeding on the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Benign neoplasia; Mandibular growth; Postoperative adaptation; Rostral mandible. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017001100604 |
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| Câmara,Antônio Carlos Lopes; Soto-Blanco,Benito; Batista,Jael Soares; Vale,André Menezes do; Feijó,Francisco Marlon Carneiro; Olinda,Robério Gomes. |
| The present study aimed to report the occurrence as well as the clinical, laboratorial, pathological and mycological findings of three outbreaks of rhinocerebral and rhinopharyngeal conidiobolomycosis in sheep from Rio Grande do Norte state, Brazil. A total of six sheep with clinical signs of conidiobolomycosis were evaluated, and information on history was obtained from ranchers. Clinical signs included depression, progressive emaciation, sero-sanguinolent nasal discharge, tachycardia, dyspnea, miosis and unilateral exophthalmia with increased ocular globe volume, corneal ulceration and nervous system signs. The main hematological alteration was neutrophilia. Serum biochemical evaluation revealed increased values for AST, GGT, creatinine, urea, and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Conidiobolus coronatus; Conidiobolomycosis; Fungal diseases; Upper respiratory system; Entomophthomycosis; Sheep. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782011000500021 |
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